I love medallion quilts--easy ones, that is. This cheery little quilt uses 20 10" squares or 10 Fat Sixths (12"x 22"). If you have a Layer Cake pack of 40 squares, you could sort them into 2 stacks and make 2 quilts. It never hurts to get ahead on those baby quilt gifts.
The quilt finishes 36"x45" or 47"x 56" with a 6" cut border.
The cover shows the center squares of just 2 different fabric for a Four Patch look. It can certainly be 4 different fabrics. This is also one that could feature a special center piece. The center is 18" finished. If your center piece is not that big, put a border around it. That border might be good to set it off, anyway.