When you really, really can't cut it. As with those fabulous prints, like Laura Gunn's here for Michael Miller. There is so little math involved, you don't waste any of your precious fabric.
Take 2 yards and only slice it once. Insert a row of 6 simple blocks and you have a quilt top. Additional yardage is 3/4 each of the Frame, Centers/Binding, and Background. The Background can be light, so the blocks stand out in the row. Or it can be a color to blend with the Theme fabric, or even the Theme itself, so the blocks float.
The quilt top finishes 54"x 69", and with only 6 blocks, it finishes fast.